Bitter Orange (Citrus aurantium) is used as a flavouring and acidifying agent for food and as herbal medicine to treat anxiety, nausea, indigestion, constipation, cancer and cardio-vascular disease. It is also used as an appetite suppressant to treat obesity and as a stimulant to improve athletic performance, energy, mental focus and cognition. Bitter orange contains essential oils and many flavonoid-type compounds with antimicrobial, antioxidant, cytotoxic, anxiolytic, anti-diabetic, anti-obesity, and anti-inflammatory activities. These compounds include an active phenylethanolamine type alkaloid called p-synephrine, which is chemically similar to adrenergic agents and has similar effects to ephedra without the cardio-vascular side effects.
Suntar, I., et al., An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent. Oxidative Medicine and Cellular Longevity, 2018. 2018: p. 7864269.
What Extremely Alive Tonics Contain Bitter Orange?